Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b
Sphingosine-1-phosphate (S1P) is a potent lipid mediator that exerts its activity via activation
of five different G protein–coupled receptors, designated as S1P1–5. This potent lipid
mediator is synthesized from the sphingosine precursor by two sphingosine kinases (SphK1
and 2) and must be exported to exert extracellular signaling functions. We recently identified
Mfsd2b as the S1P transporter in the hematopoietic system. However, the sources of
sphingosine for S1P synthesis and the transport mechanism of Mfsd2b in erythrocytes …
of five different G protein–coupled receptors, designated as S1P1–5. This potent lipid
mediator is synthesized from the sphingosine precursor by two sphingosine kinases (SphK1
and 2) and must be exported to exert extracellular signaling functions. We recently identified
Mfsd2b as the S1P transporter in the hematopoietic system. However, the sources of
sphingosine for S1P synthesis and the transport mechanism of Mfsd2b in erythrocytes …
